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Neurobiological findings indicate a pivotal role of the mesolimbic pathway, comprising the ventral striatum, and ventromedial prefrontal cortex VMPFC in PG. Because the VMPFC is a structure that mainly depends on DA projections that communicate with limbic structures to integrate information, dysfunctional DA transmission could be the underlying deficit causing the VMPFC dysfunctions in PG. However, numerous other neurotransmitter systems are probably also engaged and may interact during the processing of positive and negative feedback.
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Whereas in substance one arm bandit games free download, drugs and drug-associated stimuli may elicit DA release in the ventral striatum and reinforce drug intake during the acquisition of a substance use disorder, chronic drug intake is associated with neuroadaptation of glutamatergic neurotransmission in the ventral and dorsal striatum and limbic cortex McFarland et al. In addition, cue exposure has been found to depend on projections of glutamatergic neurons from the prefrontal cortex to the nucleus accumbens LaLumiere and Kalivas, 2008.
Blocking the release of glutamate has prevented drug seeking behavior in animals as well as in human substance dependent persons Krupitsky et al.
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