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Although this neurobehavioral effect may well increase the risk of developing PG, direct evidence for this relationship is lacking. We were interested in i mean activity change following feedback, and ii trial-by-trial correlation with RPE values-as an indicator of local reward processing. Avoiding confounding behavioral effects during fMRI, we assessed risk-taking behavior offline. On the basis little more action elvis the hypothesis that DAs prevent decreased dopaminergic transmission with negative RPE values, we predicted that in contrast to OFF and LD, DAs would relatively increase mean feedback-induced activation and desensitize the reward system toward RPE.
We further hypothesized that reward desensitization would be associated with increased risk-taking behavior in the offline task. We selected patients without history of overt neuropsychiatric conditions including depression, dementia, or any impulse control disorder. All subjects provided written little more action elvis consent to participate.
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